P51S (p.Pro51Ser) variant of PARP2 (Poly [ADP-ribose] polymerase 2)
P51S (p.Pro51Ser) in PARP2 (Poly [ADP-ribose] polymerase 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P51S (p.Pro51Ser) variant details
- p.Pro51Ser
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.16
- REVEL 0.06
- CADD 11.80
- PolyPhen-2 0.05
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available