F10 (Coagulation factor X) variants and mutations

F10 (also known as Coagulation factor X) is a human protein-coding gene encoding a coagulation factor X protein. After activation to factor Xa, it converts prothrombin to thrombin within the prothrombinase complex and therefore occupies a central position in the coagulation cascade. Biallelic deficiency causes a rare bleeding disorder, while factor Xa is a major target of direct oral anticoagulants. This analysis covers 766 F10 variants and mutations. Of these, 78% have computational variant effect predictions. Disease context includes factor X deficiency, congenital factor X deficiency, and venous thromboembolism. Example F10 variants include G2E, G2V, and G2W.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable F10 variants

Examples include G2E, G2V, G2W, G2R, G2G, R3C, R3H, R3L. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.