L45P (p.Leu45Pro) variant of F10 (Coagulation factor X)
L45P (p.Leu45Pro) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
L45P (p.Leu45Pro) variant details
- p.Leu45Pro
- ExAC rs776481640
- TOPMed rs776481640
- gnomAD rs776481640
- Missense
- Variant Prioritization Score for Impact Estimate 0.521
- REVEL 0.56
- CADD 20.20
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available