R27C (p.Arg27Cys) variant of F10 (Coagulation factor X)
R27C (p.Arg27Cys) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
R27C (p.Arg27Cys) variant details
- p.Arg27Cys
- cosmic curated COSV65021
- TOPMed rs1041970620
- gnomAD rs1041970620
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.32
- CADD 16.60
- PolyPhen-2 0.61
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available