L35R (p.Leu35Arg) variant of F10 (Coagulation factor X)
L35R (p.Leu35Arg) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data, published literature, and structural context.
L35R (p.Leu35Arg) variant details
- p.Leu35Arg
- gnomAD 13-113129485-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.756
- REVEL 0.80
- MetaLR 0.96
- MetaSVM 1.07
- CADD 25.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available