L53P (p.Leu53Pro) variant of F10 (Coagulation factor X)
L53P (p.Leu53Pro) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data, published literature, and structural context.
L53P (p.Leu53Pro) variant details
- p.Leu53Pro
- gnomAD 13-113129539-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.781
- REVEL 0.85
- MetaLR 1.00
- MetaSVM 0.90
- CADD 25.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available