E59K (p.Glu59Lys) variant of F10 (Coagulation factor X)
E59K (p.Glu59Lys) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes population frequency data, published literature, and structural context.
E59K (p.Glu59Lys) variant details
- p.Glu59Lys
- gnomAD 13-113129556-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.856
- REVEL 0.90
- MetaLR 0.99
- MetaSVM 0.98
- CADD 26.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available