R28K (p.Arg28Lys) variant of F10 (Coagulation factor X)
R28K (p.Arg28Lys) in F10 (Coagulation factor X) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
R28K (p.Arg28Lys) variant details
- p.Arg28Lys
- gnomAD 13-113129464-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.235
- REVEL 0.14
- MetaLR 0.67
- MetaSVM -0.22
- CADD 2.49
- PolyPhen-2 0.01
- SIFT 0.86
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available