CDK7 (Cyclin-dependent kinase 7) variants and mutations

CDK7 (also known as Cyclin-dependent kinase 7) is a human protein-coding gene encoding a cyclin-dependent kinase 7 protein. It activates other cell-cycle CDKs and also phosphorylates RNA polymerase II as part of TFIIH, linking cell-cycle control with transcription. Some cancers show strong dependence on CDK7-driven transcription, motivating development of selective inhibitors. This analysis covers 452 CDK7 variants and mutations. Of these, 82% have computational variant effect predictions. Disease context includes HIV infectious disease, neurodegenerative disease, and hypertensive disorder. Example CDK7 variants include A2T, A2S, and A2D.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CDK7 variants

Examples include A2T, A2S, A2D, A2V, A2A, L3V, L3L, L3Q. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.