R8W (p.Arg8Trp) variant of CDK7 (Cyclin-dependent kinase 7)
R8W (p.Arg8Trp) in CDK7 (Cyclin-dependent kinase 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
R8W (p.Arg8Trp) variant details
- p.Arg8Trp
- NCI-TCGA Cosmic COSV5650
- cosmic curated COSV56508
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.42
- REVEL 0.22
- CADD 32.00
- PolyPhen-2 0.85
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available