L45P (p.Leu45Pro) variant of CDK7 (Cyclin-dependent kinase 7)
L45P (p.Leu45Pro) in CDK7 (Cyclin-dependent kinase 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data, published literature, and structural context.
L45P (p.Leu45Pro) variant details
- p.Leu45Pro
- gnomAD 5-69252425-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.569
- REVEL 0.51
- CADD 28.30
- PolyPhen-2 0.88
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available
- Literature evidence available