TSLP (Thymic stromal lymphopoietin) variants and mutations

TSLP (also known as Thymic stromal lymphopoietin) is a human protein-coding gene encoding a thymic stromal lymphopoietin protein. When released from stressed barrier tissues, it activates dendritic cells and type 2 immune responses after allergen or tissue injury. Excess signaling is important in asthma and atopic dermatitis and is therapeutically targetable with TSLP-blocking antibodies. This analysis covers 399 TSLP variants and mutations. Of these, 81% have computational variant effect predictions. Disease context includes asthma, sinusitis, and chronic rhinosinusitis with nasal polyps. Example TSLP variants include F2I, F2L, and F2S.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable TSLP variants

Examples include F2I, F2L, F2S, F2F, P3R, F4C, F4L, A5G. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.