L22P (p.Leu22Pro) variant of TSLP (Thymic stromal lymphopoietin)
L22P (p.Leu22Pro) in TSLP (Thymic stromal lymphopoietin) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
L22P (p.Leu22Pro) variant details
- p.Leu22Pro
- ExAC rs774856310
- TOPMed rs774856310
- gnomAD rs774856310
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.418
- REVEL 0.42
- CADD 25.90
- PolyPhen-2 0.99
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available