F31V (p.Phe31Val) variant of TSLP (Thymic stromal lymphopoietin)
F31V (p.Phe31Val) in TSLP (Thymic stromal lymphopoietin) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
F31V (p.Phe31Val) variant details
- p.Phe31Val
- ExAC rs753025356
- TOPMed rs753025356
- gnomAD rs753025356
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.44
- CADD 26.80
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available