G24R (p.Gly24Arg) variant of TSLP (Thymic stromal lymphopoietin)
G24R (p.Gly24Arg) in TSLP (Thymic stromal lymphopoietin) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
G24R (p.Gly24Arg) variant details
- p.Gly24Arg
- rs1179899313
- ClinGen CA360602522
- ClinVar RCV004172194
- TOPMed rs1179899313
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.15
- CADD 17.00
- PolyPhen-2 0.38
- SIFT 0.45
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available