L22I (p.Leu22Ile) variant of TSLP (Thymic stromal lymphopoietin)
L22I (p.Leu22Ile) in TSLP (Thymic stromal lymphopoietin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
L22I (p.Leu22Ile) variant details
- p.Leu22Ile
- gnomAD 5-111071954-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.175
- REVEL 0.11
- CADD 19.10
- PolyPhen-2 0.85
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available