TAS2R5 (Taste receptor type 2 member 5) variants and mutations
TAS2R5 (also known as Taste receptor type 2 member 5) is a human protein-coding gene encoding a taste receptor type 2 member 5 protein. A G protein-coupled bitter-taste receptor expressed in subsets of taste cells. It can signal through gustducin, PLC-beta2, and TRPM5 to help detect the chemical composition of food and other substances. This analysis covers 627 TAS2R5 variants and mutations. Of these, 99% have computational variant effect predictions. Disease context includes venous thromboembolism, colorectal adenocarcinoma, and head and neck squamous cell carcinoma. Example TAS2R5 variants include L2L, S3G, and S3N.
Variant analysis overview
- Gene: TAS2R5
- Protein: Taste receptor type 2 member 5
- UniProt accession: Q9NYW4
- Organism: Homo sapiens
- Variants analyzed: 627
- Variant scope: all variants
- Completed: 2026-05-30
Variant and mutation evidence
- Variant composition: 323 unspecified-consequence records; 114 synonymous variants; 149 missense variants; 22 frameshift variants; 8 stop-gained variants; 8 in-frame deletions; 1 in-frame insertions; 1 stop lost; 1 substitution
- Prediction scores: 619 variants have prediction scores (99% of the analyzed set).
Clinical, disease, and population context
- Disease context: 25 disease associations are represented. Top associations: venous thromboembolism, colorectal adenocarcinoma, head and neck squamous cell carcinoma, myeloid sarcoma, neoplasm, diabetic nephropathy, cancer, Lewy body dementia, prostate adenocarcinoma, acute myeloid leukemia by FAB classification, diabetes mellitus, acute myeloid leukemia.
Protein structure and variant hotspots
- Protein features: 7 transmembrane segments; 1 post-translational modification sites.
- Structural context: 297 variants have structural context.
Data sources
Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, AlphaFold DB, gnomAD constraint, Open Targets, PharmGKB, MaveDB, LitVar.
Notable TAS2R5 variants
Examples include L2L, S3G, S3N, S3S, A4T, A4G, G5A, G5D. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.
- L2L (p.Leu2Leu), gnomAD 7-141790367-G-T, CADD 1.14
- S3G (p.Ser3Gly), gnomAD 7-141790368-A-G, REVEL 0.03, ESM-1b 0.00
- S3N (p.Ser3Asn), gnomAD 7-141790369-G-A, REVEL 0.03, ESM-1b 0.00
- S3S (p.Ser3Ser), rs372174387, gnomAD 7-141790370-C-T, CADD 0.24
- A4T (p.Ala4Thr), TOPMed rs951414842, gnomAD rs951414842, REVEL 0.02, ESM-1b 0.00
- A4G (p.Ala4Gly), gnomAD 7-141790372-C-G, REVEL 0.04, ESM-1b 0.00
- G5A (p.Gly5Ala), ExAC rs768974258, gnomAD rs768974258, REVEL 0.01, ESM-1b 0.00
- G5D (p.Gly5Asp), NCI-TCGA TCGA novel, REVEL 0.02, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- G5G (p.Gly5Gly), gnomAD 7-141790376-C-G, CADD 2.84
- L6R (p.Leu6Arg), ESP rs376893938, TOPMed rs376893938, gnomAD rs376893938, REVEL 0.09, ESM-1b 0.00
- L6P (p.Leu6Pro), rs1800428238, gnomAD 7-141790373-T-TG, CADD 14.90
- L6L (p.Leu6Leu), rs1248299202, gnomAD 7-141790379-A-G, CADD 4.36
- G7V (p.Gly7Val), ExAC rs762038613, gnomAD rs762038613, REVEL 0.05, ESM-1b 0.00
- G7R (p.Gly7Arg), gnomAD 7-141790380-G-C, REVEL 0.10, ESM-1b 0.00
- G7G (p.Gly7Gly), rs1800428437, gnomAD 7-141790382-A-G, CADD 5.32
- L8L (p.Leu8Leu), rs912541312, gnomAD 7-141790385-G-A, CADD 5.64
- L9L (p.Leu9Leu), rs1800428529, gnomAD 7-141790388-G-A, CADD 6.85
- M10I (p.Met10Ile), ExAC rs772598052, gnomAD rs772598052, REVEL 0.07, ESM-1b 0.00
- M10V (p.Met10Val), gnomAD 7-141790389-A-G, REVEL 0.07, ESM-1b 0.00
- V12G (p.Val12Gly), TOPMed rs1800428631, REVEL 0.10, ESM-1b 0.52, Uncertain significance, not specified
- V12L (p.Val12Leu), ExAC rs773755643, TOPMed rs773755643, gnomAD rs773755643, REVEL 0.14, ESM-1b 0.00
- V12M (p.Val12Met), NCI-TCGA Cosmic COSV9992, REVEL 0.05, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- A13Q (p.Ala13Gln), rs1800428659, gnomAD 7-141790396-TG-T, CADD 14.50
- A13V (p.Ala13Val), gnomAD 7-141790399-C-T, REVEL 0.12, ESM-1b 0.00
- V15D (p.Val15Asp), Ensembl rs1800428723, REVEL 0.16, ESM-1b 0.16
- V15A (p.Val15Ala), gnomAD 7-141790405-T-C, REVEL 0.03, ESM-1b 0.00
- V15V (p.Val15Val), gnomAD 7-141790406-T-G, CADD 0.92
- E16A (p.Glu16Ala), gnomAD rs1186012404, REVEL 0.18, ESM-1b 0.14
- E16Q (p.Glu16Gln), NCI-TCGA TCGA novel, REVEL 0.18, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- E16* (p.Glu16Ter), gnomAD 7-141790407-G-T, CADD 34.00
- E16K (p.Glu16Lys), gnomAD 7-141790407-G-A, REVEL 0.18, ESM-1b 0.18
- F17C (p.Phe17Cys), rs1386406855, ClinGen CA369561561, ClinVar RCV004104406, TOPMed rs1386406855, REVEL 0.13, ESM-1b 0.00, Uncertain significance, not specified
- L18F (p.Leu18Phe), ExAC rs760959195, gnomAD rs760959195, REVEL 0.09, ESM-1b 0.00
- L18L (p.Leu18Leu), rs149618467, gnomAD 7-141790415-C-A, CADD 0.30
- I19V (p.Ile19Val), TOPMed rs1204489854, gnomAD rs1204489854, REVEL 0.06, ESM-1b 0.00
- I19L (p.Ile19Leu), gnomAD 7-141790416-A-C, REVEL 0.06, ESM-1b 0.00
- I19I (p.Ile19Ile), rs753858883, gnomAD 7-141790418-C-T, CADD 1.28
- G20S (p.Gly20Ser), rs2234013, UniProt VAR 053343, 1000Genomes rs2234013, ESP rs2234013, REVEL 0.14, ESM-1b 0.00
- G20D (p.Gly20Asp), gnomAD 7-141790420-G-A, REVEL 0.14, ESM-1b 1.00
- L21F (p.Leu21Phe), TOPMed rs1800429151, REVEL 0.08, ESM-1b 0.00
- L21V (p.Leu21Val), gnomAD rs1184913845, REVEL 0.07, ESM-1b 0.00
- I22T (p.Ile22Thr), ExAC rs750558319, TOPMed rs750558319, gnomAD rs750558319, REVEL 0.09, ESM-1b 0.00
- I22K (p.Ile22Lys), gnomAD 7-141790423-T-TGA, CADD 21.70
- I22F (p.Ile22Phe), gnomAD 7-141790425-A-T, REVEL 0.15, ESM-1b 0.00
- I22L (p.Ile22Leu), gnomAD 7-141790425-A-C, REVEL 0.02, ESM-1b 0.00
- I22M (p.Ile22Met), gnomAD 7-141790426-T-TGG, CADD 16.40
- G23E (p.Gly23Glu), ExAC rs751545813, TOPMed rs751545813, gnomAD rs751545813, REVEL 0.30, ESM-1b 0.67
- G23R (p.Gly23Arg), NCI-TCGA Cosmic COSV5609, REVEL 0.26, ESM-1b 1.00, Variant assessed as somatic; moderate impact.
- N24S (p.Asn24Ser), rs370940395, ClinGen CA4519212, ClinVar RCV004471484, ExAC rs370940395, REVEL 0.40, ESM-1b 0.50, Uncertain significance, not specified
- G25R (p.Gly25Arg), ExAC rs780941034, gnomAD rs780941034, REVEL 0.35, ESM-1b 1.00
- G25V (p.Gly25Val), gnomAD rs1161550220, REVEL 0.27, ESM-1b 0.00
- G25G (p.Gly25Gly), gnomAD 7-141790436-A-G, CADD 2.52
- S26G (p.Ser26Gly), Ensembl rs2117231828, REVEL 0.05, ESM-1b 0.00
- S26I (p.Ser26Ile), rs2227264, UniProt VAR 020203, 1000Genomes rs2227264, ESP rs2227264, REVEL 0.04, ESM-1b 0.00
- S26N (p.Ser26Asn), 1000Genomes rs2227264, ESP rs2227264, ExAC rs2227264, TOPMed rs2227264, REVEL 0.03, ESM-1b 0.22
- L27R (p.Leu27Arg), gnomAD 7-141790441-T-G, REVEL 0.25, ESM-1b 1.00
- L27L (p.Leu27Leu), rs1401523986, gnomAD 7-141790442-G-C, CADD 0.12
- V28V (p.Val28Val), gnomAD 7-141790445-G-A, CADD 1.12
- V29A (p.Val29Ala), TOPMed rs1454447711, gnomAD rs1454447711, REVEL 0.13, ESM-1b 0.00, Uncertain significance, not specified
- V29F (p.Val29Phe), ExAC rs779757760, gnomAD rs779757760, REVEL 0.14, ESM-1b 0.00
- V29I (p.Val29Ile), ExAC rs779757760, gnomAD rs779757760, REVEL 0.04, ESM-1b 0.00
- V29D (p.Val29Asp), gnomAD 7-141790447-T-A, REVEL 0.16, ESM-1b 1.00
- S31R (p.Ser31Arg), NCI-TCGA Cosmic COSV5609, REVEL 0.26, ESM-1b 0.41, Variant assessed as somatic; moderate impact.
- S31F (p.Ser31Phe), rs774810427, gnomAD 7-141790450-GGA-G, CADD 23.20
- F32I (p.Phe32Ile), NCI-TCGA Cosmic COSV5609, REVEL 0.05, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- F32L (p.Phe32Leu), ESP rs372017115, ExAC rs372017115, TOPMed rs372017115, gnomAD rs372017115, REVEL 0.02, ESM-1b 0.00
- F32S (p.Phe32Ser), gnomAD 7-141790456-T-C, REVEL 0.12, ESM-1b 0.00
- F32F (p.Phe32Phe), gnomAD 7-141790457-T-C, CADD 1.43
- R33G (p.Arg33Gly), TOPMed rs1476244401, gnomAD rs1476244401, REVEL 0.09, ESM-1b 0.00
- E34* (p.Glu34Ter), NCI-TCGA TCGA novel, Variant assessed as somatic; high impact.
- E34K (p.Glu34Lys), TOPMed rs1001956582, gnomAD rs1001956582, REVEL 0.17, ESM-1b 0.60
- E34Q (p.Glu34Gln), TOPMed rs1001956582, gnomAD rs1001956582, REVEL 0.14, ESM-1b 0.47
- W35* (p.Trp35Ter), ExAC rs768238191, gnomAD rs768238191, CADD 33.00
- I36M (p.Ile36Met), gnomAD rs1337651412, REVEL 0.05, ESM-1b 0.00
- R37T (p.Arg37Thr), rs1482588189, TOPMed rs1482588189, gnomAD rs1482588189, REVEL 0.21, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- R37R (p.Arg37Arg), rs1214374380, gnomAD 7-141790470-A-C, CADD 2.86
- F39C (p.Phe39Cys), ExAC rs779252554, gnomAD rs779252554, REVEL 0.18, ESM-1b 0.00
- F39L (p.Phe39Leu), NCI-TCGA Cosmic COSV5609, ESM-1b 0.00, AlphaMissense 0.47, Variant assessed as somatic; moderate impact.
- F39V (p.Phe39Val), NCI-TCGA Cosmic COSV5609, REVEL 0.06, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- F39F (p.Phe39Phe), gnomAD 7-141790478-C-T, CADD 2.75
- N40D (p.Asn40Asp), ExAC rs748637440, gnomAD rs748637440, REVEL 0.07, ESM-1b 0.00
- N40S (p.Asn40Ser), 1000Genomes rs144615570, ESP rs144615570, ExAC rs144615570, TOPMed rs144615570, REVEL 0.04, ESM-1b 0.00, Uncertain significance
- N40T (p.Asn40Thr), rs144615570, ClinGen CA4519223, ClinVar RCV004471481, 1000Genomes rs144615570, REVEL 0.04, ESM-1b 0.00, Uncertain significance, not specified
- W41* (p.Trp41Ter), 1000Genomes rs566687143
- W41C (p.Trp41Cys), NCI-TCGA TCGA novel, 1000Genomes rs566687143, ESM-1b 0.00, AlphaMissense 0.19, Variant assessed as somatic; moderate impact.
- W41L (p.Trp41Leu), NCI-TCGA TCGA novel, REVEL 0.06, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- W41R (p.Trp41Arg), rs747446102, ClinGen CA4519224, ClinVar RCV004109243, ExAC rs747446102, REVEL 0.06, ESM-1b 0.00, Uncertain significance, not specified
- W41S (p.Trp41Ser), gnomAD 7-141790483-G-C, REVEL 0.06, ESM-1b 0.00
- S42F (p.Ser42Phe), ExAC rs771211675, gnomAD rs771211675, REVEL 0.08, ESM-1b 0.63
- S42S (p.Ser42Ser), gnomAD 7-141790487-C-G, CADD 3.18
- S43L (p.Ser43Leu), Ensembl rs2117231923, REVEL 0.22, ESM-1b 0.00
- S43P (p.Ser43Pro), gnomAD 7-141790488-T-C, REVEL 0.06, ESM-1b 0.00
- S43S (p.Ser43Ser), rs1432630198, gnomAD 7-141790490-A-C, CADD 6.33
- Y44* (p.Tyr44Ter), gnomAD rs1338681043, CADD 34.00
- Y44C (p.Tyr44Cys), ExAC rs776934413, TOPMed rs776934413, gnomAD rs776934413, REVEL 0.22, ESM-1b 0.00
- Y44F (p.Tyr44Phe), ExAC rs776934413, TOPMed rs776934413, gnomAD rs776934413, REVEL 0.13, ESM-1b 0.00
- Y44Y (p.Tyr44Tyr), gnomAD 7-141790493-T-C, CADD 6.00
- N45H (p.Asn45His), gnomAD 7-141790494-A-C, REVEL 0.14, ESM-1b 0.00
- N45N (p.Asn45Asn), rs534241411, gnomAD 7-141790496-C-T, CADD 6.76
- L46P (p.Leu46Pro), NCI-TCGA Cosmic COSV5609, ESM-1b 0.99, AlphaMissense 0.44, Variant assessed as somatic; high impact.
- L46V (p.Leu46Val), rs759494239, NCI-TCGA Cosmic COSV5609, ExAC rs759494239, gnomAD rs759494239, ESM-1b 0.00, AlphaMissense 0.11, Variant assessed as somatic; moderate impact.
- I47F (p.Ile47Phe), gnomAD 7-141790500-A-T, REVEL 0.07, ESM-1b 0.58
- I47L (p.Ile47Leu), gnomAD 7-141790500-A-C, REVEL 0.10, ESM-1b 0.00
- I48F (p.Ile48Phe), rs765326902, NCI-TCGA Cosmic COSV5609, ExAC rs765326902, gnomAD rs765326902, REVEL 0.05, ESM-1b 0.00, Uncertain significance, not specified
- L49R (p.Leu49Arg), Ensembl rs1298868564, REVEL 0.23, ESM-1b 0.08
- L49L (p.Leu49Leu), rs775480705, gnomAD 7-141790506-C-T, CADD 5.65
- G50A (p.Gly50Ala), gnomAD 7-141790507-TG-T, CADD 21.30
- G50S (p.Gly50Ser), gnomAD 7-141790509-G-A, REVEL 0.17, ESM-1b 0.00
- G50D (p.Gly50Asp), gnomAD 7-141790510-G-A, REVEL 0.22, ESM-1b 1.00
- L51L (p.Leu51Leu), gnomAD 7-141790514-G-C, CADD 7.04
- A52D (p.Ala52Asp), ESP rs376612372, ExAC rs376612372, TOPMed rs376612372, gnomAD rs376612372, REVEL 0.25, ESM-1b 1.00, Uncertain significance
- A52S (p.Ala52Ser), TOPMed rs1408887785, gnomAD rs1408887785, REVEL 0.10, ESM-1b 0.00
- A52T (p.Ala52Thr), TOPMed rs1408887785, gnomAD rs1408887785, REVEL 0.16, ESM-1b 0.00
- A52V (p.Ala52Val), rs376612372, ClinGen CA4519230, ClinVar RCV004334726, ESP rs376612372, REVEL 0.20, ESM-1b 0.28, Uncertain significance, not specified
- C54* (p.Cys54Ter), gnomAD 7-141790523-C-A, CADD 25.30
- R55* (p.Arg55Ter), TOPMed rs961601864, gnomAD rs961601864, CADD 26.50
- R55L (p.Arg55Leu), 1000Genomes rs147887777, ESP rs147887777, ExAC rs147887777, TOPMed rs147887777, REVEL 0.14, ESM-1b 1.00
- R55Q (p.Arg55Gln), 1000Genomes rs147887777, ESP rs147887777, ExAC rs147887777, TOPMed rs147887777, REVEL 0.07, ESM-1b 1.00
- F56Y (p.Phe56Tyr), ExAC rs755912766, TOPMed rs755912766, gnomAD rs755912766, REVEL 0.17, ESM-1b 1.00
- F56F (p.Phe56Phe), gnomAD 7-141790529-T-C, CADD 5.05
- L57I (p.Leu57Ile), TOPMed rs1224044365, gnomAD rs1224044365, REVEL 0.12, ESM-1b 0.00
- L57P (p.Leu57Pro), TOPMed rs1800430961, ESM-1b 1.00, AlphaMissense 0.62
- L57V (p.Leu57Val), TOPMed rs1224044365, gnomAD rs1224044365, REVEL 0.05, ESM-1b 0.00
- L57L (p.Leu57Leu), rs765902246, gnomAD 7-141790532-C-T, CADD 2.61
- L58L (p.Leu58Leu), rs1800431035, gnomAD 7-141790533-C-T, CADD 3.87
- L61P (p.Leu61Pro), gnomAD 7-141790543-T-C, REVEL 0.26, ESM-1b 1.00
- I62M (p.Ile62Met), Ensembl rs267601321, REVEL 0.12, ESM-1b 0.00
- I62V (p.Ile62Val), gnomAD rs1320315257, REVEL 0.09, ESM-1b 0.00
- I63L (p.Ile63Leu), Ensembl rs1584787083, REVEL 0.06, ESM-1b 0.00
- D65G (p.Asp65Gly), Ensembl rs1584787086, REVEL 0.17, ESM-1b 0.38
- D65N (p.Asp65Asn), TOPMed rs1418715767, REVEL 0.15, ESM-1b 0.00
- D65D (p.Asp65Asp), gnomAD 7-141790556-C-T, CADD 3.29
- L66* (p.Leu66Ter), ExAC rs753562198, TOPMed rs753562198, gnomAD rs753562198, CADD 34.00
- L66F (p.Leu66Phe), Ensembl rs1800431301, ESM-1b 0.00, AlphaMissense 0.22
- L66S (p.Leu66Ser), ExAC rs753562198, TOPMed rs753562198, gnomAD rs753562198, REVEL 0.08, ESM-1b 0.00
- S67R (p.Ser67Arg), gnomAD rs1800431328, REVEL 0.11, ESM-1b 0.21, Uncertain significance, not specified
- S67G (p.Ser67Gly), gnomAD 7-141790560-A-G, REVEL 0.03, ESM-1b 0.00
- L68S (p.Leu68Ser), gnomAD 7-141790564-T-C, REVEL 0.23, ESM-1b 0.00
- P70S (p.Pro70Ser), NCI-TCGA Cosmic COSV5609, gnomAD rs1800431397, REVEL 0.01, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- P70P (p.Pro70Pro), rs1584787091, gnomAD 7-141790571-A-C, CADD 0.47
- L71F (p.Leu71Phe), gnomAD 7-141790572-C-T, REVEL 0.06, ESM-1b 0.00
- F72I (p.Phe72Ile), gnomAD 7-141790575-T-A, REVEL 0.16, ESM-1b 0.00
- F72F (p.Phe72Phe), rs1399559294, gnomAD 7-141790577-C-T, CADD 5.77
- S74T (p.Ser74Thr), Ensembl rs1584787094, REVEL 0.11, ESM-1b 0.00
- S74G (p.Ser74Gly), gnomAD 7-141790581-A-G, REVEL 0.09, ESM-1b 0.00
- S74R (p.Ser74Arg), gnomAD 7-141790583-C-G, REVEL 0.06, ESM-1b 0.00
- S75G (p.Ser75Gly), ExAC rs754628636, gnomAD rs754628636, REVEL 0.15, ESM-1b 0.00
- S75N (p.Ser75Asn), ExAC rs778467467, TOPMed rs778467467, gnomAD rs778467467, REVEL 0.11, ESM-1b 0.00
- S75T (p.Ser75Thr), ExAC rs778467467, TOPMed rs778467467, gnomAD rs778467467, REVEL 0.17, ESM-1b 0.00
- S75del (p.Ser75del), rs762272557, gnomAD 7-141790580-GAGC-, CADD 8.86
- S75S (p.Ser75Ser), rs1255886219, gnomAD 7-141790586-C-T, CADD 2.62
- R76C (p.Arg76Cys), rs201786698, ClinGen CA4519239, NCI-TCGA Cosmic COSV5609, ClinVar RCV004471482, REVEL 0.11, ESM-1b 0.00, Uncertain significance, not specified
- R76H (p.Arg76His), rs200318022, NCI-TCGA Cosmic COSV5609, 1000Genomes rs200318022, ExAC rs200318022, REVEL 0.04, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- R76S (p.Arg76Ser), 1000Genomes rs201786698, ExAC rs201786698, TOPMed rs201786698, gnomAD rs201786698, REVEL 0.07, ESM-1b 0.00, Uncertain significance
- R76P (p.Arg76Pro), gnomAD 7-141790588-G-C, REVEL 0.14, ESM-1b 0.00
- R76R (p.Arg76Arg), gnomAD 7-141790589-T-C, CADD 0.40
- W77S (p.Trp77Ser), gnomAD 7-141790591-G-C, REVEL 0.18, ESM-1b 0.00
- L78F (p.Leu78Phe), gnomAD 7-141790593-C-T, REVEL 0.04, ESM-1b 0.00
- R79C (p.Arg79Cys), 1000Genomes rs148686585, ESP rs148686585, ExAC rs148686585, TOPMed rs148686585, REVEL 0.04, ESM-1b 0.00
- R79H (p.Arg79His), rs142235954, NCI-TCGA Cosmic COSV5609, ESP rs142235954, ExAC rs142235954, REVEL 0.04, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- R79S (p.Arg79Ser), gnomAD 7-141790596-C-A, REVEL 0.03, ESM-1b 0.00
- Y80* (p.Tyr80Ter), ExAC rs746078573, gnomAD rs746078573, CADD 33.00
- Y80C (p.Tyr80Cys), ExAC rs776900780, TOPMed rs776900780, gnomAD rs776900780, REVEL 0.20, ESM-1b 0.00
- Y80F (p.Tyr80Phe), ExAC rs776900780, TOPMed rs776900780, gnomAD rs776900780, REVEL 0.04, ESM-1b 0.00
- Y80N (p.Tyr80Asn), ESP rs370040721, ExAC rs370040721, TOPMed rs370040721, gnomAD rs370040721, REVEL 0.18, ESM-1b 0.00
- Y80H (p.Tyr80His), gnomAD 7-141790599-T-C, REVEL 0.12, ESM-1b 0.00
- L81F (p.Leu81Phe), 1000Genomes rs574839256, ExAC rs574839256, gnomAD rs574839256, ESM-1b 0.00, AlphaMissense 0.20
- L81R (p.Leu81Arg), Ensembl rs1940033815, REVEL 0.24, ESM-1b 1.00
- L81V (p.Leu81Val), 1000Genomes rs574839256, ExAC rs574839256, gnomAD rs574839256, REVEL 0.01, ESM-1b 0.00
- L81H (p.Leu81His), gnomAD 7-141790603-T-A, REVEL 0.12, ESM-1b 1.00
- L81P (p.Leu81Pro), gnomAD 7-141790603-T-C, REVEL 0.21, ESM-1b 0.55
- S82N (p.Ser82Asn), ExAC rs750150959, TOPMed rs750150959, gnomAD rs750150959, REVEL 0.07, ESM-1b 0.00
- S82G (p.Ser82Gly), gnomAD 7-141790605-A-G, REVEL 0.02, ESM-1b 0.00
- I83T (p.Ile83Thr), ExAC rs763022785, TOPMed rs763022785, gnomAD rs763022785, REVEL 0.12, ESM-1b 0.00, Uncertain significance, not specified
- I83I (p.Ile83Ile), rs1158278782, gnomAD 7-141790610-C-A, CADD 2.44
- F84S (p.Phe84Ser), gnomAD 7-141790610-CT-C, CADD 19.30
- W85* (p.Trp85Ter), TOPMed rs1273346847
- W85R (p.Trp85Arg), ExAC rs767381785, gnomAD rs767381785, REVEL 0.13, ESM-1b 1.00
- L87V (p.Leu87Val), gnomAD 7-141790620-C-G, REVEL 0.09, ESM-1b 0.00
- L87L (p.Leu87Leu), rs1227255423, gnomAD 7-141790620-C-T, CADD 4.09
Public TAS2R5 analysis runs
- TAS2R5 analysis run — TAS2R5 (627 variants) — completed 2026-05-30