L46V (p.Leu46Val) variant of TAS2R5 (Taste receptor type 2 member 5)
L46V (p.Leu46Val) in TAS2R5 (Taste receptor type 2 member 5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L46V (p.Leu46Val) variant details
- p.Leu46Val
- rs759494239
- NCI-TCGA Cosmic COSV5609
- ExAC rs759494239
- gnomAD rs759494239
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- ESM-1b 0.00
- AlphaMissense 0.11
- MetaLR 0.16
- MetaSVM -0.98
- PolyPhen-2 0.97
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available