AURKA (Aurora kinase A) variants and mutations

AURKA (also known as Aurora kinase A) is a human protein-coding gene encoding an aurora kinase A protein. It coordinates centrosome maturation, spindle assembly, and chromosome segregation during mitosis. Overexpression or amplification can promote chromosomal instability and tumor progression, making its kinase activity a target of anticancer drug development. This analysis covers 967 AURKA variants and mutations. Of these, 53% have computational variant effect predictions. Disease context includes neurodegenerative disease, Alzheimer disease, and Parkinson disease. Example AURKA variants include M1?, D2E, and R3*.

Variant analysis overview

Gene: AURKA
Protein: Aurora kinase A
UniProt accession: O14965
Organism: Homo sapiens
Variants analyzed: 967
Variant scope: all variants
Completed: 2026-08-20

Variant and mutation evidence

Variant composition: 734 unspecified-consequence records; 16 frameshift variants; 86 missense variants; 115 synonymous variants; 2 in-frame deletions; 2 stop lost; 8 stop-gained variants; 4 substitution
Prediction scores: 512 variants have prediction scores (53% of the analyzed set).

Clinical, disease, and population context

Disease context: 25 disease associations are represented. Top associations: neurodegenerative disease, Alzheimer disease, Parkinson disease, lysosomal storage disease, multiple sclerosis, mature T-cell and NK-cell non-Hodgkin lymphoma, response to xenobiotic stimulus, alcohol drinking, cancer, prostate adenocarcinoma, colorectal cancer, breast cancer.

Protein structure and variant hotspots

Protein features: 1 domains; 5 binding sites; 5 post-translational modification sites.
Structural context: 632 variants have structural context.
PTM context: 12 variants overlap post-translational modification sites.

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable AURKA variants

Examples include M1?, D2E, R3*, R3D, R3G, R3L, R3Q, S4A. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.

AURKA analysis run — AURKA (967 variants) — completed 2026-08-20