R24L (p.Arg24Leu) variant of AURKA (Aurora kinase A)
R24L (p.Arg24Leu) in AURKA (Aurora kinase A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
R24L (p.Arg24Leu) variant details
- p.Arg24Leu
- ExAC rs779597046
- TOPMed rs779597046
- gnomAD rs779597046
- Missense
- Variant Prioritization Score for Impact Estimate 0.48
- REVEL 0.35
- CADD 24.20
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the Middle Eastern population (allele frequency 0.00035)
- Structural context available