K63N (p.Lys63Asn) variant of AURKA (Aurora kinase A)
K63N (p.Lys63Asn) in AURKA (Aurora kinase A) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
K63N (p.Lys63Asn) variant details
- p.Lys63Asn
- rs373634582
- ClinGen CA9917483
- ClinVar RCV004343770
- ESP rs373634582
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.27
- REVEL 0.11
- CADD 23.50
- PolyPhen-2 0.88
- SIFT 0.05
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available