R56C (p.Arg56Cys) variant of AURKA (Aurora kinase A)

Name: AURKA R56C (p.Arg56Cys) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

R56C (p.Arg56Cys) in AURKA (Aurora kinase A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.

R56C (p.Arg56Cys) variant details

p.Arg56Cys
rs375420005
cosmic curated COSV57168
ESP rs375420005
ExAC rs375420005
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.288
REVEL 0.15
CADD 23.20
PolyPhen-2 0.01
SIFT 0.00
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Finnish in Finland (FIN) population (allele frequency 0.00015)
Structural context available