S66C (p.Ser66Cys) variant of AURKA (Aurora kinase A)
S66C (p.Ser66Cys) in AURKA (Aurora kinase A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
S66C (p.Ser66Cys) variant details
- p.Ser66Cys
- TOPMed rs1281596637
- gnomAD rs1281596637
- Missense
- Variant Prioritization Score for Impact Estimate 0.196
- REVEL 0.08
- CADD 15.10
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available