K77R (p.Lys77Arg) variant of AURKA (Aurora kinase A)
K77R (p.Lys77Arg) in AURKA (Aurora kinase A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
K77R (p.Lys77Arg) variant details
- p.Lys77Arg
- TOPMed rs1403493502
- gnomAD rs1403493502
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.06
- CADD 23.40
- PolyPhen-2 0.69
- SIFT 0.14
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available