R46W (p.Arg46Trp) variant of AURKA (Aurora kinase A)
R46W (p.Arg46Trp) in AURKA (Aurora kinase A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
R46W (p.Arg46Trp) variant details
- p.Arg46Trp
- ExAC rs763087319
- TOPMed rs763087319
- gnomAD rs763087319
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- REVEL 0.35
- CADD 22.20
- PolyPhen-2 0.01
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available