P70L (p.Pro70Leu) variant of AURKA (Aurora kinase A)
P70L (p.Pro70Leu) in AURKA (Aurora kinase A) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P70L (p.Pro70Leu) variant details
- p.Pro70Leu
- rs767515238
- ClinGen CA9917480
- cosmic curated COSV10045
- ClinVar RCV004353705
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.13
- CADD 7.26
- PolyPhen-2 0.01
- SIFT 0.08
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available