F31I (p.Phe31Ile) variant of AURKA (Aurora kinase A)
F31I (p.Phe31Ile) in AURKA (Aurora kinase A) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data, published literature, and structural context.
F31I (p.Phe31Ile) variant details
- p.Phe31Ile
- rs2273535
- ClinGen CA118383
- cosmic curated COSV57167
- ClinVar RCV000007021
- Benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.0615
- REVEL 0.05
- CADD 1.76
- PolyPhen-2 0.00
- SIFT 0.43
- ClinVar: Benign (not provided)
- EBI: Benign (in dbSNP:rs2273535)
- UniProt: Benign (in dbSNP:rs2273535)
- Most common in the HGDP:PIMA population (allele frequency 0.95)
- Structural context available
- Cited in: The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. (PMID 10511710)
- Cited in: Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. (PMID 12881723)