IL17F (Interleukin-17F) variants and mutations

IL17F (also known as Interleukin-17F) is a human protein-coding gene encoding an interleukin-17F protein. It promotes epithelial and stromal antimicrobial responses, chemokine production, and neutrophil recruitment, often together with IL-17A. Dominant-negative or loss-of-function variants can predispose to chronic mucocutaneous candidiasis. This analysis covers 412 IL17F variants and mutations. Of these, 95% have computational variant effect predictions. Disease context includes Chronic mucocutaneous candidosis, psoriasis, and psoriasis vulgaris. Example IL17F variants include M1I, T2K, and T2T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable IL17F variants

Examples include M1I, T2K, T2T, V3V, K4N, K4R, p.Lys4dup, K4E. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.