K35R (p.Lys35Arg) variant of IL17F (Interleukin-17F)
K35R (p.Lys35Arg) in IL17F (Interleukin-17F) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified; Candidiasis, familial, 6. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
K35R (p.Lys35Arg) variant details
- p.Lys35Arg
- rs750915214
- ClinGen CA3854446
- ClinVar RCV001864992
- ClinVar RCV005584907
- Uncertain significance
- not specified; Candidiasis, familial, 6
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.01
- MetaLR 0.03
- MetaSVM -1.02
- CADD 6.84
- PolyPhen-2 0.01
- SIFT 0.20
- ClinVar: Uncertain significance (not specified; Candidiasis, familial, 6)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available