I59V (p.Ile59Val) variant of IL17F (Interleukin-17F)
I59V (p.Ile59Val) in IL17F (Interleukin-17F) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
I59V (p.Ile59Val) variant details
- p.Ile59Val
- ExAC rs777653129
- TOPMed rs777653129
- gnomAD rs777653129
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.08
- MetaLR 0.05
- MetaSVM -1.04
- CADD 7.57
- PolyPhen-2 0.00
- SIFT 0.09
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 0.00014)
- Structural context available