V68I (p.Val68Ile) variant of IL17F (Interleukin-17F)
V68I (p.Val68Ile) in IL17F (Interleukin-17F) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as conflicting interpretations in the context of not specified; Candidiasis, familial, 6. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
V68I (p.Val68Ile) variant details
- p.Val68Ile
- rs569473195
- ClinGen CA3854426
- NCI-TCGA Cosmic COSV6023
- ClinVar RCV002994858
- Conflicting interpretations
- not specified; Candidiasis, familial, 6
- Missense
- Variant Prioritization Score for Impact Estimate 0.0846
- REVEL 0.05
- MetaLR 0.02
- MetaSVM -1.07
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 0.82
- ClinVar: Conflicting classifications of pathogenicity (not specified; Candidiasis, familial, 6)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:BEB population (allele frequency 0.0051)
- Structural context available