K43R (p.Lys43Arg) variant of IL17F (Interleukin-17F)
K43R (p.Lys43Arg) in IL17F (Interleukin-17F) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
K43R (p.Lys43Arg) variant details
- p.Lys43Arg
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.124
- REVEL 0.05
- MetaLR 0.03
- MetaSVM -1.03
- CADD 8.10
- PolyPhen-2 0.19
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available