CDK1 (Cyclin-dependent kinase 1) variants and mutations

CDK1 (also known as Cyclin-dependent kinase 1) is a human protein-coding gene encoding a cyclin-dependent kinase 1 protein. It is the central kinase that drives cells into mitosis and coordinates chromosome condensation, nuclear-envelope breakdown, spindle assembly, and other mitotic events. Because proliferating tumor cells depend on tightly regulated CDK1 activity, its pathway is extensively studied as an anticancer target. This analysis covers 377 CDK1 variants and mutations. Of these, 83% have computational variant effect predictions. Disease context includes neurodegenerative disease, Alzheimer disease, and Parkinson disease. Example CDK1 variants include E2K, E2G, and E2E.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CDK1 variants

Examples include E2K, E2G, E2E, E2D, D3H, D3G, D3D, D3E. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.