L70F (p.Leu70Phe) variant of CDK1 (Cyclin-dependent kinase 1)
L70F (p.Leu70Phe) in CDK1 (Cyclin-dependent kinase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
L70F (p.Leu70Phe) variant details
- p.Leu70Phe
- ExAC rs780626115
- gnomAD rs780626115
- Missense
- Variant Prioritization Score for Impact Estimate 0.546
- REVEL 0.47
- AlphaMissense 0.46
- MetaLR 0.10
- MetaSVM -0.65
- CADD 26.80
- PolyPhen-2 0.97
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available