Q28R (p.Gln28Arg) variant of CDK1 (Cyclin-dependent kinase 1)
Q28R (p.Gln28Arg) in CDK1 (Cyclin-dependent kinase 1) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
Q28R (p.Gln28Arg) variant details
- p.Gln28Arg
- ESP rs377117179
- TOPMed rs377117179
- gnomAD rs377117179
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.405
- REVEL 0.27
- CADD 21.10
- PolyPhen-2 0.01
- SIFT 0.85
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available