R50W (p.Arg50Trp) variant of CDK1 (Cyclin-dependent kinase 1)
R50W (p.Arg50Trp) in CDK1 (Cyclin-dependent kinase 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
R50W (p.Arg50Trp) variant details
- p.Arg50Trp
- rs1312102931
- NCI-TCGA Cosmic COSV5734
- cosmic curated COSV57349
- TOPMed rs1312102931
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.572
- REVEL 0.46
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available