RAMP1 (O60894) variants and mutations

RAMP1 (also known as O60894) is a human protein-coding gene encoding a receptor activity-modifying protein 1 protein. An accessory membrane protein that transports CALCRL to the cell surface and changes the receptor's ligand specificity. Together with CALCRL it forms the CGRP receptor complex, linking RAMP1 to vascular signaling and pain pathways. This analysis covers 386 RAMP1 variants and mutations. Of these, 87% have computational variant effect predictions. Disease context includes migraine disorder, type 1 diabetes mellitus, and diabetes mellitus. Example RAMP1 variants include A2S, A2T, and A2D.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable RAMP1 variants

Examples include A2S, A2T, A2D, A2V, A2A, R3P, R3W, R3G. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.