MOG (Q16653) variants and mutations

MOG (also known as Q16653) is a human protein-coding gene encoding a myelin-oligodendrocyte glycoprotein protein. It is displayed on the outer surface of central-nervous-system myelin and oligodendrocytes and is accessible to circulating antibodies. Pathogenic antibodies against MOG define MOG antibody-associated disease, an inflammatory demyelinating disorder distinct from multiple sclerosis and aquaporin-4-positive neuromyelitis optica. This analysis covers 535 MOG variants and mutations. Of these, 76% have computational variant effect predictions. Disease context includes transient neonatal diabetes mellitus, narcolepsy-cataplexy syndrome, and hereditary disease. Example MOG variants include A2T, A2S, and A2V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable MOG variants

Examples include A2T, A2S, A2V, A2A, S3N, S3R, S3S, L4V. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.