S27R (p.Ser27Arg) variant of MOG (Q16653)
S27R (p.Ser27Arg) in MOG (Q16653) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
S27R (p.Ser27Arg) variant details
- p.Ser27Arg
- TOPMed rs1767303830
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.13
- MetaLR 0.05
- MetaSVM -1.07
- CADD 4.45
- PolyPhen-2 0.22
- SIFT 0.57
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available