HLA-DRA (P01903) variants and mutations

HLA-DRA (also known as P01903) is a human protein-coding gene encoding a HLA class II histocompatibility antigen, DR alpha chain protein. It provides the relatively conserved alpha chain of HLA-DR antigen-presenting complexes, which activate CD4 T cells by displaying peptides from extracellular proteins. Variation in its partner beta chains largely determines peptide specificity and many HLA-DR-associated disease risks. This analysis covers 611 HLA-DRA variants and mutations. Of these, 85% have computational variant effect predictions. Disease context includes Graham Little-Piccardi-Lassueur syndrome, lichen planopilaris, and Sepsis. Example HLA-DRA variants include M1?, A2G, and A2T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable HLA-DRA variants

Examples include M1?, A2G, A2T, A2V, I3K, I3T, I3V, I3M. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.