T66M (p.Thr66Met) variant of HLA-DRA (P01903)
T66M (p.Thr66Met) in HLA-DRA (P01903) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
T66M (p.Thr66Met) variant details
- p.Thr66Met
- rs536514150
- 1000Genomes rs536514150
- ExAC rs536514150
- gnomAD rs536514150
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- REVEL 0.14
- CADD 26.40
- PolyPhen-2 1.00
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:ACB population (allele frequency 0.0054)
- Structural context available