R69W (p.Arg69Trp) variant of HLA-DRA (P01903)
R69W (p.Arg69Trp) in HLA-DRA (P01903) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
R69W (p.Arg69Trp) variant details
- p.Arg69Trp
- rs751526731
- NCI-TCGA Cosmic COSV6662
- cosmic curated COSV66622
- ExAC rs751526731
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.214
- REVEL 0.18
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available