CYP4F2 (Cytochrome P450 4F2) variants and mutations

CYP4F2 (also known as Cytochrome P450 4F2) is a human protein-coding gene encoding a cytochrome P450 4F2 protein. It oxidizes vitamin K1, vitamin E, fatty acids, and eicosanoids. Common functional variants can reduce vitamin K catabolism and modestly increase warfarin dose requirements. This analysis covers 962 CYP4F2 variants and mutations. Of these, 94% have computational variant effect predictions. Disease context includes peripheral neuropathy, diabetic neuropathy, and response to anticoagulant. Example CYP4F2 variants include S2F, Q3*, and Q3H.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CYP4F2 variants

Examples include S2F, Q3*, Q3H, Q3K, L4P, S5G, S5R, S7F. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.