WEE1 (Wee1-like protein kinase) variants and mutations

WEE1 (also known as Wee1-like protein kinase) is a human protein-coding gene encoding a wee1-like protein kinase protein. It restrains entry into mitosis by inhibitory phosphorylation of CDK1, giving cells time to complete DNA replication and repair damage. Tumor cells under high replication stress can depend heavily on this checkpoint, making WEE1 inhibition an anticancer strategy. This analysis covers 1,095 WEE1 variants and mutations. Of these, 87% have computational variant effect predictions. Disease context includes neurodegenerative disease, actinic keratosis, and autoimmune disorder of central nervous system. Example WEE1 variants include S2R, S2C, and S2G.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable WEE1 variants

Examples include S2R, S2C, S2G, S2I, S2T, S2N, S2S, F3L. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.