I26L (p.Ile26Leu) variant of WEE1 (Wee1-like protein kinase)
I26L (p.Ile26Leu) in WEE1 (Wee1-like protein kinase) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
I26L (p.Ile26Leu) variant details
- p.Ile26Leu
- gnomAD rs1849534084
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.186
- REVEL 0.05
- CADD 20.60
- PolyPhen-2 0.00
- SIFT 0.76
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 8.8e-05)
- Structural context available