VSIR (Q9H7M9) variants and mutations

VSIR (also known as Q9H7M9) is a human protein-coding gene encoding a v-type immunoglobulin domain-containing suppressor of T-cell activation protein. It suppresses T-cell activation and helps maintain immune quiescence, particularly within myeloid-rich environments. Its inhibitory activity in tumors makes it an emerging immune-checkpoint target for cancer therapy. This analysis covers 586 VSIR variants and mutations. Of these, 84% have computational variant effect predictions. Disease context includes hypothyroidism, alcohol drinking, and neoplasm. Example VSIR variants include G2S, V3A, and V3F.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable VSIR variants

Examples include G2S, V3A, V3F, P4R, T5A, A6T, A6V, L7P. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.