P38L (p.Pro38Leu) variant of VSIR (Q9H7M9)
P38L (p.Pro38Leu) in VSIR (Q9H7M9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
P38L (p.Pro38Leu) variant details
- p.Pro38Leu
- rs758679492
- NCI-TCGA Cosmic COSV9982
- ExAC rs758679492
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- REVEL 0.16
- CADD 21.50
- PolyPhen-2 0.18
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 0.00016)
- Structural context available