R74H (p.Arg74His) variant of VSIR (Q9H7M9)
R74H (p.Arg74His) in VSIR (Q9H7M9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
R74H (p.Arg74His) variant details
- p.Arg74His
- rs1397974862
- NCI-TCGA Cosmic COSV5646
- gnomAD rs1397974862
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.366
- REVEL 0.24
- CADD 23.50
- PolyPhen-2 0.78
- SIFT 0.17
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available