CD276 (CD276 antigen) variants and mutations

CD276 (also known as CD276 antigen) is a human protein-coding gene encoding a CD276 antigen protein. It modulates immune responses and is frequently overexpressed on tumor cells and tumor-associated vasculature. Its restricted expression in many normal tissues and high expression in several cancers make it an active target for antibody, CAR-T, and radioligand strategies. This analysis covers 913 CD276 variants and mutations. Of these, 82% have computational variant effect predictions. Disease context includes response to statin, Abnormality of the skeletal system, and head and neck squamous cell carcinoma. Example CD276 variants include L2V, L2L, and L2R.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CD276 variants

Examples include L2V, L2L, L2R, R3C, R3H, R3P, R4G, R4L. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.