R3C (p.Arg3Cys) variant of CD276 (CD276 antigen)
R3C (p.Arg3Cys) in CD276 (CD276 antigen) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
R3C (p.Arg3Cys) variant details
- p.Arg3Cys
- rs770116040
- NCI-TCGA Cosmic COSV5920
- cosmic curated COSV59204
- ExAC rs770116040
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.08
- REVEL 0.04
- CADD 10.80
- PolyPhen-2 0.00
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available